Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy
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چکیده
منابع مشابه
Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy
Over the past 40 years, a number of seemingly unrelated mechanisms have been implicated in the early stages of glucose-mediated damage responsible for diabetic complications. Starting in 2000, a series of publications showed that each of these mechanisms reflects a single hyperglycemia-induced process: overproduction of superoxide by the mitochondrial electron transport chain. This discovery cr...
متن کاملReactive oxygen species-regulated signaling pathways in diabetic nephropathy.
Diabetic nephropathy is characterized by excessive deposition of extracellular matrix (ECM) in the kidney. TGF-beta1 has been identified as the key mediator of ECM accumulation in diabetic kidney. High glucose induces TGF-beta1 in glomerular mesangial and tubular epithelial cells and in diabetic kidney. Antioxidants inhibit high glucose-induced TGF-beta1 and ECM expression in glomerular mesangi...
متن کاملReactive oxygen species in diabetic nephropathy: friend or foe?
Based on the numerous cellular and animal studies over the last decades, it has been postulated that reactive oxygen species (ROS) are important secondary messengers for signalling pathways associated with apoptosis, proliferation, damage and inflammation. Their adverse effects were considered to play a leading role in the onset and progression of type 1 and type 2 diabetes mellitus as well as ...
متن کاملMitochondria and reactive oxygen species.
Copyright © 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/HYPERTENSIONAHA.109.130054 2009;53;885-892; originally published online Apr 27, 2009; Hypertension Francesco Addabbo, Monica Montagnani and Michael S. Goligorsky Mitochondria and Reactiv...
متن کاملCardiac mitochondria and reactive oxygen species generation.
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the electron transport chain and the proton motive force consisting of a membrane potential (ΔΨ) and a proton gradient (ΔpH). Several factors controllin...
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ژورنال
عنوان ژورنال: The Review of Diabetic Studies
سال: 2015
ISSN: 1613-6071,1614-0575
DOI: 10.1900/rds.2015.12.134